Goat Follistatin Like Protein 3 ELISA Kit (RMEK-0151606)
Cat. No.: RMEK-0151606
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 20 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Goat |
|---|---|
| Assay Time | 1.20 h |
Target Information
| Target Symbol | FSTL3 |
|---|---|
| UniProt ID | O95633 |
| Biomarker of SCs/CSCs | Luminal A Breast Cancer |
| Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
| Cellular Localization | [Isoform 1]: Secreted. [Isoform 2]: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. |
| Involvement in Disease | A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11; 19)(q13; p13) with CCDN1. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
