Guinea Pig Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe ELISA Kit (RMEK-0151919)
Cat. No.: RMEK-0151919
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Guinea Pig |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | LFNG |
|---|---|
| UniProt ID | Q8NES3 |
| Biomarker of SCs/CSCs | Hepatic Cancer |
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning (By similarity). |
| Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein. |
| Post-transcriptional Modifications | A soluble form may be derived from the membrane form by proteolytic processing. |
| Involvement in Disease | Spondylocostal dysostosis 3, autosomal recessive (SCDO3): A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
