Human Ectodysplasin-A ELISA Kit (RMEK-0152572)
Cat. No.: RMEK-0152572
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Human |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | EDA |
|---|---|
| UniProt ID | Q92838 |
| Biomarker of SCs/CSCs | Non Small Cell Lung Cancer |
| Function | Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion (By similarity). [Isoform 1]: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. [Isoform 3]: Binds only to the receptor EDA2R. |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. [Ectodysplasin-A, secreted form]: Secreted. |
| Post-transcriptional Modifications | N-glycosylated. Processing by furin produces a secreted form. |
| Involvement in Disease | Ectodermal dysplasia 1, hypohidrotic, X-linked (XHED): A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. It is the most common form of over 150 clinically distinct ectodermal dysplasias. The disease is caused by variants affecting the gene represented in this entry. Tooth agenesis, selective, X-linked, 1 (STHAGX1): A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
