Human GFAP Matched Antibody Pair Kit (RMAB-0252016)
Cat. No.: RMAB-0252016
Category: Antibody Pair
INQUIRY
5 x 96 tests
Human GFAP Matched Antibody Pair Kits include a capture and a biotinylated detector antibody pair, along with a calibrated protein standard, suitable for sandwich ELISA. The Matched Antibody Pair Kit can be used to quantify native and recombinant human GFAP.
Product Features
| Species Reactivity | Human |
|---|---|
| Range | 15.6 pg/mL - 1000 pg/mL |
| Sensitivity | 3.47 pg/mL |
| Applications | ELISA |
| Key Features | Unlabeled capture antibody, biotin-labeled detection antibody and calibrated protein standard; For economical ELISA and ELISA-based assay development; Reacts with: Human; Range: 15.6 pg/mL - 1000 pg/mL |
Target Information
| Target Symbol | GFAP |
|---|---|
| Target Name | Glial fibrillary acidic protein |
| UniProt ID | P14136 |
| Cellular Localization | Cytoplasm. Associated with intermediate filaments. |
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Involvement in Disease | Defects in GFAP are a cause of Alexander disease (ALEXD). Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. |
| Post-translational Modifications | Phosphorylated by PKN1. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage & Shipping | Store at -20°C. Please refer to protocols. |
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For research use only. Not for clinical use.
