Human HDAC1 Antibody Pair - BSA and Azide free (RMAB-0252213)
Cat. No.: RMAB-0252213
Category: Antibody Pair
INQUIRY
10 x 96 tests
Human HDAC1 Antibody Pair - BSA and Azide free is a matched pair of unconjugated recombinant rabbit monoclonal capture and detection antibodies used to quantify human HDAC1 in sandwich ELISAs and many other pair-based applications._x000D_
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Human |
| Range | 0.08 ng/mL - 10 ng/mL |
| Sample Type | Cell Lysate |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Human |
Target Information
| Target Symbol | HDAC1 |
|---|---|
| Target Name | Histone deacetylase 1 |
| UniProt ID | Q13547 |
| Cellular Localization | Nucleus. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. |
| Post-translational Modifications | Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1. Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Ubiquitinated by CHFR, leading to its degradation by the proteasome. |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
|---|
For research use only. Not for clinical use.
