Human Recombinant DKK-1

Dickkopf-related protein 1. A family of human DKK-related genes composed of DKK-1, DKK-2, DKK-3, and DKK-4 have been characterized together with a unique DKK-3 related protein termed Soggy. DKK-1 has been shown to support the generation of myeloid-derived suppressor cells. DKK-1 from thrombocytes is an important regulator of leukocyte infiltration and induces Th2 cell polarization and potentiates Th2 cell cytokine expression. DKK-1 has also been shown to drive cardiac and retinal differentiation from induced pluripotent stem. Protein contains a His-residue tag at the carboxyl end of the polypeptide chain.