Imatinib mesylate, Tyrosine kinase inhibitor (RMML-00120825)
Cat. No.: RMML-00120825
Category: Inhibitors & Activators
INQUIRY
100 mg
20 mg
Potent, selective tyrosine kinase inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Potent, selective tyrosine kinase inhibitor; CAS Number: 220127-57-1; Purity: > 98%; Soluble in water to 100 mM and in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | Tyrosine Kinase |
|---|---|
| Biological Description | Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL. |
| Alternative Names | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate, CGP 57148, CGP 57148B, Genfatinib, Gleevec, Glivec, Imatinib methanesulfonate, STI-571 |
| CAS Number | 220127-57-1 |
| Chemical Name | 4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide mesylate |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O |
| Molecular Formula | C29H31N7O.CH4SO3 |
| Molecular Weight | 589.73 Da |
| PubChem Identifier | 123596 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in water to 100 mM and in DMSO to 100 mM |
| Storage & Shipping | Shipped at room temperature. Store at -20°C. Store under desiccating conditions. |
For research use only. Not for clinical use.
