IQ-1 (RMML-00120562)
Cat. No.: RMML-00120562
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
IQ-1 selectively inhibits p300-dependent β-catenin signaling by binding to the PR72/130 subunit of protein phosphatase PP2A, leading to decreased phosphorylation of the β-catenin coactivator, p300, and decreased affinity of p300 for β-catenin. IQ-1 thereby inhibits β-catenin/p300 interaction while increasing β-catenin/CBP mediated transcription. LUsed with Wnt3a to maintain pluripotency of mouse embryonic stem. Enhances expansion of mouse ES-derived cardiovascular progenitor cells. Induces the conversion of cancer cells to a side population of cancer stem-like cells with high levels of drμg resistance and tumorigenicity.
Product Features
| Purity | ≥ 98% |
|---|---|
| Applications | Expansion, Maintenance |
| Cross Reactivity | Human, Mouse, Non-Human Primate, Other, Rat |
Compound Information
| Target Pathways | WNT |
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| CAS Number | 331001-62-8 |
| Molecular Formula | C₂₁H₂₂N₄O₂ |
Storage & Shipping
| Handling | Refer to SDS for further information. |
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For research use only. Not for clinical use.
