Monkey Catenin delta 1(CTNND1) ELISA Kit (RMEK-0153149)
Cat. No.: RMEK-0153149
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Monkey |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | CTNND1 |
|---|---|
| UniProt ID | O60716 |
| Biomarker of SCs/CSCs | Head and Neck Cancer |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Cellular Localization | Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. CDH1 enhances cell membrane localization. Isoforms 4A and 1AB are excluded from the nucleus. [Isoform 1A]: Nucleus. [Isoform 2A]: Nucleus. [Isoform 3A]: Nucleus. |
| Domain | A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted. ARM repeats 1 to 5 mediate interaction with cadherins. |
| Post-transcriptional Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Involvement in Disease | Blepharocheilodontic syndrome 2 (BCDS2): A form of blepharocheilodontic syndrome, a rare autosomal dominant disorder. It is characterized by lower eyelid ectropion, upper eyelid distichiasis, euryblepharon, bilateral cleft lip and palate, and features of ectodermal dysplasia, including hair anomalies, conical teeth and tooth agenesis. An additional rare manifestation is imperforate anus. There is considerable phenotypic variability among affected individuals. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
