Monkey GATA Binding Protein 3 ELISA Kit

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Monkey GATA Binding Protein 3 ELISA Kit (RMEK-0153255)

Cat. No.: RMEK-0153255

Category: ELISA Kits

INQUIRY 1 x 96 tests

This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Product Features

Species Reactivity	Monkey
Assay Time	1.5 h

Target Information

Target Symbol	GATA3
UniProt ID	P23771
Biomarker of SCs/CSCs	Triple Negative Breast Cancer
Function	Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Cellular Localization	Nucleus.
Domain	Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation. The YxKxHxxxRP motif is critical for DNA-binding and function.
Involvement in Disease	Hypoparathyroidism, sensorineural deafness, and renal disease (HDR): A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia. The disease is caused by variants affecting the gene represented in this entry.

Storage & Shipping

Storage	Store at 2-8°C
Shipping	Gel Packs
Stability	The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

For research use only. Not for clinical use.