Monkey Parathyroid hormone Receptor ELISA Kit (RMEK-0153363)
Cat. No.: RMEK-0153363
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Monkey |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | PTH1R |
|---|---|
| UniProt ID | Q03431 |
| Function | Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Post-transcriptional Modifications | N-glycosylated. |
| Involvement in Disease | Metaphyseal chondrodysplasia, Jansen type (MCDJ): A rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones. The disease is caused by variants affecting the gene represented in this entry. Chondrodysplasia Blomstrand type (BOCD): Severe skeletal dysplasia. The disease is caused by variants affecting the gene represented in this entry. Eiken syndrome (EKNS): An autosomal recessive skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation. The disease is caused by variants affecting the gene represented in this entry. Primary failure of tooth eruption (PFE): Rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
