PFI-3, bromodomain and SMARCA4 inhibitor (RMML-00120737)
Cat. No.: RMML-00120737
Category: Inhibitors & Activators
INQUIRY
5 mg
25 mg
Potent and selective bromodomain and SMARCA4 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Potent and selective bromodomain and SMARCA4 inhibitor; CAS Number: 1819363-80-8; Purity: > 98%; Soluble in DMSO to 100 mM and in ethanol to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | bromodomain, SMARCA4 |
|---|---|
| Biological Description | Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (Kd = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells. |
| CAS Number | 1819363-80-8 |
| Chemical Name | (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one |
| SMILES | C1[C@@H]2CN([C@H]1CN2C3=CC=CC=N3)/C=C/C(=O)C4=CC=CC=C4O |
| Molecular Formula | C19H19N3O2 |
| Molecular Weight | 321.37 Da |
| PubChem Identifier | 78243717 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Store in the dark. |
For research use only. Not for clinical use.
