Rabbit Hyaluronan synthase 3 ELISA Kit (RMEK-0154801)
Cat. No.: RMEK-0154801
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 34 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Rabbit |
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| Assay Time | 1.34 h |
Target Information
| Target Symbol | HAS3 |
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| UniProt ID | O00219 |
| Biomarker of SCs/CSCs | Triple Negative Breast Cancer |
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Early endosome. Travels from endoplasmic reticulum (ER), Golgi to plasma membrane. Actives only when present in plasma membrane (By similarity). O-GlcNAcylation controls its membrane localization. A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc. |
| Post-transcriptional Modifications | O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP-GlcNAc controls the level of O-GlcNAc modification. |
Storage & Shipping
| Storage | Store at 2-8°C |
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| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
