Rat Polycomb complex Protein BMI-1 ELISA Kit (RMEK-0155369)
Cat. No.: RMEK-0155369
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Rat |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | BMI1 |
|---|---|
| UniProt ID | P35226 |
| Biomarker of SCs/CSCs | Pancreatic Cancer |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Cellular Localization | Nucleus. Cytoplasm. |
| Post-transcriptional Modifications | Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
