Recombinant Human CCL4/MIP-1 beta Protein (Active)

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Recombinant Human CCL4/MIP-1 beta Protein (Active) (RMPP-00230468)

Cat. No.: RMPP-00230468

Category: Growth Factors & Cytokines

Research Area: Signal Transduction

INQUIRY 100 μg Customer Size

Product Features

Source	HEK 293 cells
Purity	> 95% SDS-PAGE. >95% as determined by SEC-HPLC.
Nature	Recombinant
Endotoxin Level	< 1.000 Eu/µg
Animal Free	No
Tags	Fc tag C-Terminus
Form	Lyophilized
Applications	HPLC; ELISA; SDS-PAGE
Key Features	Expression system: HEK 293 cells; Purity: > 95% SDS-PAGE; Endotoxin level: < 1.000 Eu/µg; Active: Yes; Tags: Fc tag C-Terminus; Suitable for: HPLC, ELISA, SDS-PAGE

Protein Information

UniProt ID	Q96RJ3
Molecular Weight	33 kDa including tags
Molecular Weight Information	As a result of glycosylation, the protein migrates as 40-45 kDa under reducing condition, and 80-100 kDa under non-reducing condition.
Sequence	SQRSRDSSVPTQCNQTECFDPLVRNCVSCELFHTPDTGHTSSLEPGTALQ PQEGSALRPDVA
Sequence Similarities	Contains 1 TNFR-Cys repeat.
Protein Length	Protein fragment
Cellular Localization	Membrane.
Tissue Specificity	Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
Function	B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Involvement in Disease	Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

Storage & Shipping

Shipping and Storage	Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. pH: 7.4Constituents: 0.75% Glycine, 0.61% Tris buffer, 5% Trehalose, L-Arginine, Sodium chlorideLyophilized from 0.22 µm filtered solution. 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5% This product is an active protein and may elicit a biological response in vivo, handle with caution.

Shipping and Storage

Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.4Constituents: 0.75% Glycine, 0.61% Tris buffer, 5% Trehalose, L-Arginine, Sodium chlorideLyophilized from 0.22 µm filtered solution.
5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%
This product is an active protein and may elicit a biological response in vivo, handle with caution.

For research use only. Not for clinical use.