Recombinant Human IL-6 Protein (Active) (RMPP-00230029)
Cat. No.: RMPP-00230029
Category: Recombinant Protein
Research Area: Stem Cells
INQUIRY
5 μg
Customer Size
Product Features
| Purity | > 90% HPLC. |
|---|---|
| Nature | Synthetic |
| Animal Free | No |
| Modifications | phospho S143 |
| Form | Liquid |
| Applications | Blocking |
| Application Note | Blocking - Blocking peptide for Anti-Dishevelled 2 (phospho S143) antibody |
| Key Features | Purity: > 90% HPLC; Suitable for: Blocking |
Protein Information
| UniProt ID | O14641 |
|---|---|
| Sequence Similarities | Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain. |
| Cellular Localization | Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta. |
| Domain | The DIX domain mediates homooligomerization. |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at -20°C. |
|---|
For research use only. Not for clinical use.
