Recombinant Human RAB23 Protein (RMPP-00230934)
Cat. No.: RMPP-00230934
Category: Recombinant Protein
Research Area: Epigenetics and Nuclear Signaling
INQUIRY
100 μg
Customer Size
Product Features
| Source | E.coli |
|---|---|
| Purity | ≥ 90% SDS-PAGE. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | His tag N-Terminus |
| Form | Liquid |
| Applications | Size Exclusion Chromatography; SDS-PAGE |
| Key Features | Expression system: E.coli; Purity: ≥ 90% SDS-PAGE; Tags: His tag N-Terminus; Suitable for: Size Exclusion Chromatography, SDS-PAGE |
Protein Information
| UniProt ID | P37231 |
|---|---|
| Molecular Weight | 35 kDa including tags |
| Molecular Weight Information | In SDS-PAGE, the protein shows a minor band corresponding to its dimer (~70 kDa); while during SEC analysis, it migrates as a single monomeric protein (~34 kDa). |
| Sequence Similarities | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Protein Length | Protein fragment |
| Cellular Localization | Nucleus. |
| Tissue Specificity | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. |
| Involvement in Disease | Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.Defects in PPARG may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3). Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. pH: 8.00Constituents: 0.584% Sodium chloride, 0.025% TCEP, 20% Glycerol (glycerin, glycerine), 0.6% Tris HCl |
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For research use only. Not for clinical use.
