Recombinant Human RYK Protein (RMPP-00230734)
Cat. No.: RMPP-00230734
Category: Growth Factors & Cytokines
Research Area: Signal Transduction
INQUIRY
20 μg
50 μg
Product Features
| Source | E.coli |
|---|---|
| Purity | > 95% SDS-PAGE. Purity is greater than 97% as determined by reducing and non-reducing SDS-PAGE and analytical HPLC. |
| Nature | Recombinant |
| Animal Free | No |
| Form | Lyophilized |
| Applications | SDS-PAGE; Functional Studies |
| Key Features | Expression system: E.coli; Purity: > 95% SDS-PAGE; Active: Yes; Suitable for: SDS-PAGE, Functional Studies |
Protein Information
| UniProt ID | P01133 |
|---|---|
| Sequence | NSYPGCPSSY DGYCLNGGVC MHIESLDSYT CNCVIGYSGD RCQTRDLRWW ELR |
| Sequence Similarities | Contains 9 EGF-like domains. Contains 9 LDL-receptor class B repeats. |
| Protein Length | Full length protein |
| Cellular Localization | Membrane. |
| Tissue Specificity | Expressed in kidney, salivary gland, cerebrum and prostate. |
| Function | EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. |
| Involvement in Disease | Hypomagnesemia 4 |
| Post-translational Modifications | O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor). |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. This product is an active protein and may elicit a biological response in vivo, handle with caution. |
|---|
For research use only. Not for clinical use.
