Recombinant Human VEGF Receptor 2 Protein (Active)

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Recombinant Human VEGF Receptor 2 Protein (Active) (RMPP-00230695)

Cat. No.: RMPP-00230695

Category: Growth Factors & Cytokines

Research Area: Immunology

INQUIRY 5 μg Customer Size

Product Features

Source	E.coli
Purity	> 95% SDS-PAGE. Protein Content and Purity (typically = 95%) determined by: Reducing and Non-reducing SDS-PAGE, UV spectroscopy at 280 nm.
Nature	Recombinant
Endotoxin Level	≤ 1.000 Eu/µg
Animal Free	No
Form	Lyophilized
Applications	SDS-PAGE; Functional Studies
Key Features	Expression system: E.coli; Purity: > 95% SDS-PAGE; Endotoxin level: ≤ 1.000 Eu/µg; Active: Yes; Suitable for: SDS-PAGE, Functional Studies

Protein Information

UniProt ID	P05231
Molecular Weight	21 kDa
Sequence	PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Sequence Similarities	Belongs to the IL-6 superfamily.
Protein Length	Full length protein
Cellular Localization	Secreted.
Function	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Involvement in Disease	Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
Post-translational Modifications	N- and O-glycosylated.

Storage & Shipping

Shipping and Storage	Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA). pH: 7.50Constituent: 0.164% Sodium phosphateLyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.164% sodium phosphate, pH 7.5 This product is an active protein and may elicit a biological response in vivo, handle with caution.

Shipping and Storage

Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
pH: 7.50Constituent: 0.164% Sodium phosphateLyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.164% sodium phosphate, pH 7.5
This product is an active protein and may elicit a biological response in vivo, handle with caution.

For research use only. Not for clinical use.