Recombinant Mouse GRO gamma Protein (RMPP-00230972)
Cat. No.: RMPP-00230972
Category: Recombinant Protein
Research Area: Immunology
INQUIRY
2 μg
Customer Size
Product Features
| Source | HEK 293 cells |
|---|---|
| Purity | > 95% SDS-PAGE. |
| Nature | Recombinant |
| Endotoxin Level | < 1.000 Eu/µg |
| Animal Free | No |
| Tags | Fc tag C-Terminus |
| Conjugation | Biotin |
| Form | Lyophilized |
| Applications | WB; ELISA; SDS-PAGE |
| Key Features | Expression system: HEK 293 cells; Purity: > 95% SDS-PAGE; Endotoxin level: < 1.000 Eu/µg; Active: Yes; Tags: Fc tag C-Terminus; Suitable for: WB, ELISA, SDS-PAGE |
Protein Information
| UniProt ID | P15391 |
|---|---|
| Molecular Weight | 56 kDa including tags |
| Sequence | LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW K |
| Sequence Similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
| Protein Length | Protein fragment |
| Cellular Localization | Membrane. |
| Function | Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
| Involvement in Disease | Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3); also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. |
| Post-translational Modifications | Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA). pH: 7.40Constituents: PBS, 5% TrehaloseLyophilized from 0.22 µm filtered solution This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
