Recombinant rhesus Monkey Flt3 ligand/Flt3L Protein (RMPP-00230993)
Cat. No.: RMPP-00230993
Category: Recombinant Protein
Research Area: Epigenetics and Nuclear Signaling
INQUIRY
2 μg
Customer Size
Product Features
| Source | Baculovirus infected insect cells |
|---|---|
| Purity | > 70% SDS-PAGE. The purity ofthis product was determined to be >70% by densitometry. Affinity purified. |
| Nature | Recombinant |
| Animal Free | No |
| Form | Liquid |
| Applications | WB; Functional Studies |
| Key Features | Expression system: Baculovirus infected insect cells; Purity: > 70% SDS-PAGE; Suitable for: WB, Functional Studies |
Protein Information
| UniProt ID | Q92769 |
|---|---|
| Molecular Weight | 92 kDa including tags |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
| Protein Length | Full length protein |
| Cellular Localization | Nucleus. |
| Tissue Specificity | Widely expressed; lower levels in brain and lung. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. |
| Post-translational Modifications | S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. |
Storage & Shipping
| Shipping and Storage | Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. pH: 7.50Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride |
|---|
For research use only. Not for clinical use.
