Sheep Factor-related Apoptosis, FAS ELISA Kit (RMEK-0155709)
Cat. No.: RMEK-0155709
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Sheep |
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| Assay Time | 1.5 h |
Target Information
| Target Symbol | FAS |
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| UniProt ID | P25445 |
| Biomarker of SCs/CSCs | Non Small Cell Lung Cancer |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft. [Isoform 2]: Secreted. [Isoform 3]: Secreted. [Isoform 4]: Secreted. [Isoform 5]: Secreted. [Isoform 6]: Secreted. |
| Domain | Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins. |
| Post-transcriptional Modifications | (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Involvement in Disease | Autoimmune lymphoproliferative syndrome 1A (ALPS1A): A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
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| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
