AG 490, JAK2/3 inhibitor (RMML-00120575)
Cat. No.: RMML-00120575
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
JAK2/3 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | JAK2/3 inhibitor; CAS Number: 133550-30-8; Purity: > 99%; Soluble in DMSO to 100 mM and in ethanol to 25 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | JAK2/3 |
|---|---|
| Biological Description | JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo. |
| CAS Number | 133550-30-8 |
| Chemical Name | (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| Molecular Formula | C17H14N2O3 |
| Molecular Weight | 294.31 Da |
| PubChem Identifier | 5328779 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 25 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
