AK-7

Selectively inhibit sirtuin 2. SIRT2 is a deacetylase that targets histone 4, α-tubulin, forkhead transcription factors of class O. As an inhibitor of SIRT2, AK-7 reduces neuronal death in Huntington’s disease. AK-7 is inactive against SIRT1 and SIRT3. AK-7 has been used for:Protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Promotes neuronal survival in Huntington’s disease mouse models. Improves the outcome of brain ischemia in mice by reportedly enhancing P38 activation levels in vitro and in vivo, significantly decreasing infarction volume, as well as promoting the recovery of neurological function in mice evaluated in behavior tests. Decreases cochlear cell apoptosis and attenuates noise-induced hearing loss, as well as reduces oxidative nuclear DNA damage and apoptosis in mouse cochlea following noise exposure. AK-7 has also been shown to reduce apoptosis of mouse inner ear HEI-OC1 cells exposed to oxidative stress in vitro.