AMD3100 octahydrochloride, CXCR4 antagonist (RMML-00120400)
Cat. No.: RMML-00120400
Category: Inhibitors & Activators
INQUIRY
1 mg
50 mg
Highly selective CXCR4 antagonist
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Highly selective CXCR4 antagonist; CAS Number: 155148-31-5; Purity: > 99%; Soluble in PBS, pH 7.2, at 10 mg/mL.; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | CXCR4 |
|---|---|
| Biological Description | Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-1 (CXCL12). It suppresses infection by HIV with an IC50 value of 1-10 ng/mL with selectivity toward CXCR4-tropic virus. Plerixafor mobilizes hematopoietic stem and progenitor cells for transplant better than G-CSF alone. It also increases T-cell trafficking in the blood and spleen as well as the central nervous system. Plerixafor regulates the growth of primary and metastic breast cancer cells and inhibits dissemination of ovarian carcinoma cells. |
| Alternative Names | AMD 3100, JM 3100, Mobozil, SID 791 |
| CAS Number | 155148-31-5 |
| Chemical Name | 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride |
| SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl |
| Molecular Formula | C28H54N8.8HCl |
| Molecular Weight | 794.48 Da |
| PubChem Identifier | 65014 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in PBS, pH 7.2, at 10 mg/mL. |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
