Anti-ADAM17/Tace Rabbit Monoclonal Antibody

Anti-ADAM17/Tace Rabbit Monoclonal Antibody (RMAB-0251506)

Cat. No.: RMAB-0251506

Category: Primary Antibodies

Research Area: Cancer Research, Stem Cells, Metabolism, Neuroscience

INQUIRY 100 μL Customer Size

Anti-ADAM17/Tace Rabbit Monoclonal Antibody. Tested in Flow Cytometry, IP, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Target Symbol	ADAM17
Target Name	Disintegrin and metalloproteinase domain-containing protein 17
UniProt ID	P78536
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
Post-translational Modifications	The precursor is cleaved by a furin endopeptidase. Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791.
Domain	Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR.The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence Similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain.

Storage Buffer	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Storage & Shipping	Dry Ice

For research use only. Not for clinical use.