Anti-Bmi1 Antibody (RMAB-0250099)
Cat. No.: RMAB-0250099
Category: Primary Antibodies
INQUIRY
100 μg
25 μg
Mouse monoclonal to Bmi1
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | BMI1/2823 |
| Form | Liquid |
| Purity | Protein A/G purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Recombinant fragment within Human Bmi1 aa 142-326. The exact sequence is proprietary. |
| Applications | IHC-P, WB, ICC/IF, Protein Array |
| Key Features | Mouse monoclonal to Bmi1; Suitable for: IHC-P, WB, ICC/IF, Protein Array; Knockout validated; Reacts with: Mouse, Human; Isotype: IgG1 |
Target Information
| Target Symbol | BMI1 |
|---|---|
| Target Name | Polycomb complex protein BMI-1 |
| UniProt ID | P35226 |
| Cellular Localization | Nucleus. Cytoplasm. |
| Function | Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Post-translational Modifications | Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. |
| Sequence Similarities | Contains 1 RING-type zinc finger. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.05% Sodium azide; Constituents: PBS, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
