Anti-Bmi1 Rabbit Monoclonal Antibody (RMAB-0251494)
Cat. No.: RMAB-0251494
Category: Primary Antibodies
Research Area: Cancer Research, Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-Bmi1 Rabbit Monoclonal Antibody. Tested in IF, WB applications. This antibody reacts with Human, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB, Flow Cyt, IF, ICC |
Target Information
| Target Symbol | BMI1 |
|---|---|
| Target Name | Polycomb complex protein BMI-1 |
| UniProt ID | P35226 |
| Function | Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Post-translational Modifications | Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. |
| Sequence Similarities | Contains 1 RING-type zinc finger. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
