Anti-COL1A2 Antibody (RMAB-0250463)
Cat. No.: RMAB-0250463
Category: Primary Antibodies
INQUIRY
100 μL
10 µL
Rabbit monoclonal to COL1A2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR27415-30 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | IHC-P, WB, Dot blot, ICC/IF, Flow Cyt (Intra) |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to COL1A2; Suitable for: IHC-P, WB, Dot blot, ICC/IF, Flow Cyt (Intra); Reacts with: Human |
Target Information
| Target Symbol | COL1A2 |
|---|---|
| Target Name | Collagen alpha-2(I) chain |
| UniProt ID | P08123 |
| Cellular Localization | Secreted > extracellular space > extracellular matrix. |
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Involvement in Disease | Ehlers-Danlos syndrome 7BOsteogenesis imperfecta 1Osteogenesis imperfecta 2Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular formOsteogenesis imperfecta 3Osteogenesis imperfecta 4A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7; 8)(p22; q13) with PLAG1. |
| Post-translational Modifications | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. |
| Domain | The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. |
| Sequence Similarities | Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
