Anti-BMP4 Rabbit Monoclonal Antibody (RMAB-0251491)
Cat. No.: RMAB-0251491
Category: Primary Antibodies
Research Area: Cardiovascular, Cancer Research, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-BMP4 Rabbit Monoclonal Antibody. Tested in IP, IF, IHC, WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to Human BMP4 aa 35 to the C-terminus. |
| Applications | WB, IHC |
Target Information
| Target Symbol | BMP4 |
|---|---|
| Target Name | Bone morphogenetic protein 4 |
| UniProt ID | P12644 |
| Function | Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. |
| Involvement in Disease | Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6); also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero. |
| Sequence Similarities | Belongs to the TGF-beta family. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
