Anti-BST2/Tetherin Antibody (RMAB-0250125)
Cat. No.: RMAB-0250125
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to BST2/Tetherin
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20202-150 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | ICC/IF, IP, Flow Cyt, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to BST2/Tetherin; Suitable for: ICC/IF, IP, Flow Cyt, WB; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | BST2 |
|---|---|
| Target Name | Bone marrow stromal antigen 2 |
| UniProt ID | Q10589 |
| Cellular Localization | Golgi apparatus > trans-Golgi network. Cell membrane. Cell membrane. Late endosome. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Targeted to the trans-Golgi network by viral VPU protein. |
| Function | May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 2S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis. |
| Post-translational Modifications | Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation. |
| Domain | The extracellular coiled coil domain is important for virus retention at the cell surface and prevention of virus spreading. |
| Sequence Similarities | Belongs to the tetherin family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
