Anti-CD11b Antibody (RMAB-0250181)
Cat. No.: RMAB-0250181
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Rat monoclonal to CD11b
Product Features
| Isotype | IgG2b |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rat |
| Clone Number | M1/70 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Tissue, cells or virus. |
| Applications | ICC/IF, Flow Cyt |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rat monoclonal to CD11b; Suitable for: ICC/IF, Flow Cyt; Reacts with: Mouse, Human |
Target Information
| Target Symbol | ITGAM |
|---|---|
| Target Name | Integrin alpha-M |
| UniProt ID | P11215 |
| Cellular Localization | Membrane. |
| Function | Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. |
| Involvement in Disease | Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. |
| Myeloma | NS1 |
| Domain | The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. |
| Sequence Similarities | Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain. |
Storage & Shipping
| Storage Buffer | Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
