Anti-CD13 Antibody (RMAB-0250191)
Cat. No.: RMAB-0250191
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to CD13
Product Features
| Isotype | IgG2a |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 22A5 |
| Form | Liquid |
| Purity | Protein A/G purified |
| Species Reactivity | Human |
| Immunogen | Tissue, cells or virus corresponding to CD13. A cell suspension containing osteoclasts from osteoclastomas |
| Applications | Flow Cyt, IHC-P |
| Key Features | Mouse monoclonal to CD13; Suitable for: Flow Cyt, IHC-P; Knockout validated; Reacts with: Human; Isotype: IgG2a |
Target Information
| Target Symbol | ANPEP |
|---|---|
| Target Name | Aminopeptidase N |
| UniProt ID | P15144 |
| Cellular Localization | Cell membrane. Cytoplasm > cytosol. A soluble form has also been detected. |
| Function | Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. |
| Post-translational Modifications | Sulfated. N- and O-glycosylated. May undergo proteolysis and give rise to a soluble form. |
| Myeloma | P3x63-Ag8.653 |
| Domain | Amino acids 26-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies). |
| Sequence Similarities | Belongs to the peptidase M1 family. |
Storage & Shipping
| Storage Buffer | Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
