Anti-CD18 (phospho S745) Antibody (RMAB-0250233)
Cat. No.: RMAB-0250233
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to CD18 (phospho S745)
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EP1288Y |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide within Human CD18 (phospho S745). The exact sequence is proprietary. |
| Applications | WB, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD18 (phospho S745); Suitable for: WB, IP; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | ITGB2 |
|---|---|
| Target Name | Integrin beta-2 |
| UniProt ID | P05107 |
| Cellular Localization | Membrane. |
| Function | Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. |
| Involvement in Disease | Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1). LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. |
| Post-translational Modifications | Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. |
| Sequence Similarities | Belongs to the integrin beta chain family. Contains 1 VWFA domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
