Anti-CD19 Antibody (RMAB-0250236)
Cat. No.: RMAB-0250236
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to CD19
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | 4C7 |
| Form | Liquid |
| Purity | Affinity purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to Human CD19. |
| Applications | IHC-P, IP, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD19; Suitable for: IHC-P, IP, WB; Reacts with: Human |
Target Information
| Target Symbol | CD19 |
|---|---|
| Target Name | B-lymphocyte antigen CD19 |
| UniProt ID | P15391 |
| Cellular Localization | Membrane. |
| Function | Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
| Involvement in Disease | Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3); also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. |
| Post-translational Modifications | Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. |
| Sequence Similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.02% Sodium azide; Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), 48% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
