Anti-CD276/B7 H3 Rabbit Monoclonal Antibody (RMAB-0251405)
Cat. No.: RMAB-0251405
Category: Primary Antibodies
Research Area: Cancer Research, Immunology, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-CD276/B7 H3 Rabbit Monoclonal Antibody. Tested in IP, WB applications. This antibody reacts with Human, Mouse.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide within Human CD276 aa 5-534 (C terminal). The exact sequence is proprietary. |
| Applications | Flow Cyt, IF, ICC |
Target Information
| Target Symbol | CD276 |
|---|---|
| Target Name | CD276 antigen |
| UniProt ID | Q5ZPR3 |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Sequence Similarities | Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
