Anti-CD32B Antibody (RMAB-0250313)
Cat. No.: RMAB-0250313
Category: Primary Antibodies
INQUIRY
100 μg
10 µg
Mouse monoclonal to CD32B
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | AT130-5 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse |
| Immunogen | Fusion protein. |
| Applications | Dot blot, Flow Cyt, ICC, IHC-Fr |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to CD32B; Suitable for: Dot blot, Flow Cyt, ICC, IHC-Fr; Reacts with: Mouse |
Target Information
| Target Symbol | FCGR2B |
|---|---|
| Target Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
| UniProt ID | P31994 |
| Cellular Localization | Cell membrane. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Involvement in Disease | A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1; 22)(q22; q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression. |
| Domain | Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. |
| Sequence Similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
