Anti-HDAC4 (phospho S246) + HDAC5 (phospho S259) + HDAC7 (phospho S155) Antibody

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Anti-HDAC4 (phospho S246) + HDAC5 (phospho S259) + HDAC7 (phospho S155) Antibody (RMAB-0250692)

Cat. No.: RMAB-0250692

Category: Primary Antibodies

INQUIRY 100 μL Customer Size

Rabbit monoclonal to HDAC4 (phospho S246) + HDAC5 (phospho S259) + HDAC7 (phospho S155)

Product Features

Isotype	IgG
Clonality	Monoclonal
Host Species	Rabbit
Clone Number	EPR22997-46
Form	Liquid
Purity	Protein A purified
Species Reactivity	Mouse, Rat, Human, Recombinant fragment
Immunogen	Synthetic peptide.
Applications	IP, WB, Dot blot
Key Features	Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to HDAC4 (phospho S246) + HDAC5 (phospho S259) + HDAC7 (phospho S155); Suitable for: IP, WB, Dot blot; Reacts with: Mouse, Rat, Human, Recombinant fragment

Target Information

Target Name	HDAC4 (phospho S246) + HDAC5 (phospho S259) + HDAC7 (phospho S155)
Cellular Localization	HDAC4: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation. HDAC5: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by CaMK. HDAC7: Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and may be due to its phosphorylation.

Target Name

HDAC4 (phospho S246) + HDAC5 (phospho S259) + HDAC7 (phospho S155)

Cellular Localization

HDAC4: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.
HDAC5: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by CaMK.
HDAC7: Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and may be due to its phosphorylation.

Storage & Shipping

Storage Buffer	pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage & Shipping	Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

For research use only. Not for clinical use.