Human/Mouse GATA4 Antibody Pair - BSA and Azide free (RMAB-0252028)
Cat. No.: RMAB-0252028
Category: Antibody Pair
INQUIRY
10 x 96 tests
Anti-GATA4 Antibody Pair - BSA and Azide free is a matched pair of unconjugated recombinant rabbit monoclonal capture and detection antibodies used to quantify human and mouse GATA4 in sandwich ELISAs and many other pair-based applications.
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Mouse, Human |
| Range | 7.8 pg/mL - 1000 pg/mL |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Mouse, Human |
Target Information
| Target Symbol | GATA4 |
|---|---|
| Target Name | Transcription factor GATA-4 |
| UniProt ID | P43694 |
| Cellular Localization | Nucleus. |
| Function | Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24000169). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735). |
| Involvement in Disease | Atrial septal defect 2Ventricular septal defect 1Tetralogy of FallotAtrioventricular septal defect 4Testicular anomalies with or without congenital heart diseaseGATA4 mutations can predispose to dilated cardiomyopathy (CMD), a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. |
| Post-translational Modifications | Methylation at Lys-300 attenuates transcriptional activity. |
| Sequence Similarities | Contains 2 GATA-type zinc fingers. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
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For research use only. Not for clinical use.
