Anti-CD44 Antibody (RMAB-0250365)
Cat. No.: RMAB-0250365
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to CD44
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | BLR038F |
| Form | Liquid |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide within Human CD44 aa 7 to the C-terminus (C terminal). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. |
| Applications | Flow Cyt, ICC, IHC-P, IP, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD44; Suitable for: Flow Cyt, ICC, IHC-P, IP, WB; Knockout validated; Reacts with: Mouse, Human |
Target Information
| Target Symbol | CD44 |
|---|---|
| Target Name | CD44 antigen |
| UniProt ID | P16070 |
| Cellular Localization | Membrane. |
| Function | Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. |
| Post-translational Modifications | Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). Phosphorylated; activation of PKC results in the dephosphorylation of Ser-76 (constitutive phosphorylation site), and the phosphorylation of Ser-672. |
| Domain | The lectin-like LINK domain is responsible for hyaluronan binding. |
| Sequence Similarities | Contains 1 Link domain. |
Storage & Shipping
| Storage Buffer | pH: 7.8; Preservative: 0.09% Sodium azide; Constituents: 98% Borate buffered saline, 0.1% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
