Anti-CD79a Monoclonal Antibody (RMAB-0250408)
Cat. No.: RMAB-0250408
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | WB, Flow Cyt, IHC, IF, ICC |
| Key Features | Bio Anti-CD79a Monoclonal Antibody. Tested in IF, WB applications. This antibody reacts with Human. |
Target Information
| Target Symbol | CD79A |
|---|---|
| Target Name | B-cell antigen receptor complex-associated protein alpha chain |
| UniProt ID | P11912 |
| Function | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells. |
| Involvement in Disease | Defects in CD79A are the cause of agammaglobulinemia type 3 (AGM3). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
