Anti-CD8 alpha Antibody (RMAB-0250414)
Cat. No.: RMAB-0250414
Category: Primary Antibodies
INQUIRY
1 mL
100 μL
Rabbit monoclonal to CD8 alpha
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | SP16 |
| Form | Liquid |
| Purity | Tissue culture supernatant |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human CD8 alpha aa 2 to the C-terminus (C terminal). The exact sequence is proprietary. |
| Applications | IHC-P, Flow Cyt |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD8 alpha; Suitable for: IHC-P, Flow Cyt; Reacts with: Human |
Target Information
| Target Symbol | CD8A |
|---|---|
| Target Name | T-cell surface glycoprotein CD8 alpha chain |
| UniProt ID | P01732 |
| Cellular Localization | Secreted and Cell membrane. |
| Epitope | C-terminus |
| Function | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. |
| Involvement in Disease | Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency). Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
| Post-translational Modifications | All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. |
| Sequence Similarities | Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.1% Sodium azide; Constituents: 1% BSA, PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
