Anti-GATA4 Antibody (RMAB-0250620)
Cat. No.: RMAB-0250620
Category: Primary Antibodies
INQUIRY
100 μL
10 µL
Rabbit monoclonal to GATA4
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR26718-103 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | Flow Cyt (Intra), IP, IHC-P, WB, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to GATA4; Suitable for: Flow Cyt (Intra), IP, IHC-P, WB, ICC/IF; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | GATA4 |
|---|---|
| Target Name | Transcription factor GATA-4 |
| UniProt ID | P43694 |
| Cellular Localization | Nucleus. |
| Function | Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24169). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:281228). Required during testicular development (PubMed:2122346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735). |
| Involvement in Disease | Atrial septal defect 2Ventricular septal defect 1Tetralogy of FallotAtrioventricular septal defect 4Testicular anomalies with or without congenital heart diseaseGATA4 mutations can predispose to dilated cardiomyopathy (CMD), a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. |
| Post-translational Modifications | Methylation at Lys-3 attenuates transcriptional activity. |
| Sequence Similarities | Contains 2 GATA-type zinc fingers. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
