Anti-CD86 Antibody - BSA free (RMAB-0250421)
Cat. No.: RMAB-0250421
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to CD86 - BSA free
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | BLR030F |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human CD86 aa 3-329 (C terminal). The exact sequence is proprietary. |
| Applications | ICC, IHC-P, IP, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD86 - BSA free; Suitable for: ICC, IHC-P, IP, WB; Reacts with: Human |
Target Information
| Target Symbol | CD86 |
|---|---|
| Target Name | T-lymphocyte activation antigen CD86 |
| UniProt ID | P42081 |
| Cellular Localization | Membrane. |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. |
| Post-translational Modifications | Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Sequence Similarities | Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.8; Preservative: 0.09% Sodium azide; Constituent: 99% Borate buffered saline |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
