Anti-Integrin alpha 6 ITGA6 Rabbit Monoclonal Antibody (RMAB-0251394)
Cat. No.: RMAB-0251394
Category: Primary Antibodies
Research Area: Stem Cells
INQUIRY
100 μL
Customer Size
Anti-Integrin alpha 6 ITGA6 Rabbit Monoclonal Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB, IHC |
Target Information
| Target Symbol | ITGA6 |
|---|---|
| Target Name | Integrin alpha-6 |
| UniProt ID | P23229 |
| Function | Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:2682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:2235176). |
| Involvement in Disease | Epidermolysis bullosa letalis, with pyloric atresia |
| Post-translational Modifications | Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-113' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro. Palmitoylation by DHHC3 enhances stability and cell surface expression. |
| Sequence Similarities | Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
