Anti-delta 1 Catenin/CAS Antibody (RMAB-0250516)
Cat. No.: RMAB-0250516
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to delta 1 Catenin/CAS
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | YE372 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human delta 1 Catenin/CAS aa 5-15 (N terminal). The exact sequence is proprietary. |
| Applications | WB, IHC-P, IP, Flow Cyt (Intra) |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to delta 1 Catenin/CAS; Suitable for: WB, IHC-P, IP, Flow Cyt (Intra); Reacts with: Human |
Target Information
| Target Symbol | CTNND1 |
|---|---|
| Target Name | Catenin delta-1 |
| UniProt ID | O60716 |
| Cellular Localization | Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. |
| Epitope | This antibody reacts with an epitope located in the N terminal region of delta 1 Catenin |
| Function | Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. |
| Post-translational Modifications | Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ. |
| Domain | A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted. |
| Sequence Similarities | Belongs to the beta-catenin family. Contains 1 ARM repeats. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
For research use only. Not for clinical use.
