Anti-ERK1 Antibody (RMAB-0250563)
Cat. No.: RMAB-0250563
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to ERK1
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | Y72 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Human, Recombinant fragment |
| Immunogen | Synthetic peptide. |
| Applications | WB, IP, IHC-P, Flow Cyt (Intra), ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to ERK1; Suitable for: WB, IP, IHC-P, Flow Cyt (Intra), ICC/IF; Knockout validated; Reacts with: Mouse, Human, Recombinant fragment |
Target Information
| Target Symbol | MAPK3 |
|---|---|
| Target Name | Mitogen-activated protein kinase 3 |
| UniProt ID | P27361 |
| Epitope | This antibody reacts with an epitope located in the N terminal region of ERK1. |
| Function | Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). |
| Post-translational Modifications | Dually phosphorylated on Thr-22 and Tyr-24, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-24. |
| Domain | The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
