Anti-P Glycoprotein Antibody (RMAB-0250946)
Cat. No.: RMAB-0250946
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to P Glycoprotein
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR10364-57 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Recombinant fragment within Human P Glycoprotein aa 35-75. The exact sequence is proprietary. |
| Applications | IHC-P, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to P Glycoprotein; Suitable for: IHC-P, WB; Knockout validated; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | ABCB1 |
|---|---|
| Target Name | ATP-dependent translocase ABCB1 |
| UniProt ID | P08183 |
| Cellular Localization | Membrane. |
| Function | Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Involvement in Disease | Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13). Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases. |
| Sequence Similarities | Belongs to the This antibody transporter superfamily. This antibody family. Multidrug resistance exporter (TC 3.A.1.21) subfamily. Contains 2 This antibody transmembrane type-1 domains. Contains 2 This antibody transporter domains. |
Storage & Shipping
| Storage Buffer | Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA, PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
