Anti-ERK1 MAPK3 Rabbit Monoclonal Antibody (RMAB-0251519)
Cat. No.: RMAB-0251519
Category: Primary Antibodies
Research Area: Stem Cells, Neuroscience
INQUIRY
100 μL
Customer Size
Anti-ERK1 MAPK3 Rabbit Monoclonal Antibody. Tested in IP, IF, IHC, WB applications. This antibody reacts with Human, Mouse.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide. |
| Applications | WB, IF |
Target Information
| Target Symbol | MAPK3 |
|---|---|
| Target Name | Mitogen-activated protein kinase 3 |
| UniProt ID | P27361 |
| Function | Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). |
| Post-translational Modifications | Dually phosphorylated on Thr-22 and Tyr-24, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-24. |
| Domain | The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
