Anti-ICAM1 Antibody (RMAB-0250723)
Cat. No.: RMAB-0250723
Category: Primary Antibodies
INQUIRY
10 μL
100 μL
Rabbit monoclonal to ICAM1
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EP1442Y |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human ICAM1 aa 1-1 |
| Applications | WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to ICAM1; Suitable for: WB, IHC-P; Reacts with: Human |
Target Information
| Target Symbol | ICAM1 |
|---|---|
| Target Name | Intercellular adhesion molecule 1 |
| UniProt ID | P05362 |
| Cellular Localization | Membrane. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. |
| Post-translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Sequence Similarities | Belongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
